gusella in a sentence

1. 08:29 - Gusella: We just need to find the right genes!

2. Gusella said that other diseases are caused by these CAG repeats in other genes.

3. "We thank the patients and their families for their commitment to research," said Dr. Gusella.

4. 11:54 - Gusella suggests these early studies haven’t stood up to scruitny, and that a more holistic approach is needed

5. 08:07 - Jim Gusella, one of the leaders of the hunt for the HD gene, addresses the WCHD on why genetics still matter in HD.

6. Gusella is interested in the fact that the age at which people have HD symptoms varies, and some of this variation is genetic.

7. Gusella suggests that many of these proposed genetic contributors are seen in one study, but fail to be replicated in another.

8. 08:11 - Gusella: Strangely, though having one mutant HD gene causes HD, having 2 copies doesn’t seem to make the disease worse.

9. 11:58 - Gusella: His team is looking at the whole genome of HD patients to try and find other genes that might change HD symptoms.

10. 12:00 - The question Gusella and colleagues are asking: “are there any genetic variations that make people have earlier or later onset of HD?”

11. 11:30 - Jim Gusella (Massachusetts General Hospital in Boston): the smaller of a person’s two CAG repeat lengths does not affect disease onset.

12. This ‘Manhattan plot’ shows Gusella’s data, from over 4,000 patient volunteers, suggesting that a genetic modifier may be found on chromosome 15.

13. They help us understand how, through evolution, nature has learned to modify the disease-causing effects of Huntington’s disease mutations,” said Dr. Gusella.

14. The study suggests that if the Ionis drug works, it should be given as early as possible before symptoms manifest, said researcher James Gusella, a study leader at Massachusetts General Hospital.